The Buffalo Bills enter the 2025 season with Super Bowl expectations, and most sportsbooks have the team near the top of their title odds ladders. The Bills have won the AFC East five years in a row and are heavy favorites to capture a sixth straight division crown this season but the ultimate goal is to get to the last game of the season. Buffalo has been unable to do that, losing twice in the AFC Championship Game and three times in the Divisional Round over the last five seasons.

One big reason the Bills are expected to be contenders is the presence of quarterback Josh Allen, who is coming off a successful 2024 season where he captured his first MVP award. Allen is a strong contender to repeat as MVP at multiple sportsbooks. Head coach Sean McDermott is back as well, looking to win double-digit games for a seventh straight year.

The Bills didn't make significant changes to a roster that made it to the AFC Championship Game last year before losing to the rival Chiefs once again in the postseason. It was Buffalo's fourth playoff loss to Kansas City in the last five seasons. Joey Bosa replaces Von Miller at edge rusher, while Larry Ogunjobi and multiple draft picks replenish the interior of the defensive line. First-round pick Maxwell Hairston replaces Rasul Douglas at cornerback, while Josh Palmer and Elijah Moore take the spots of Amari Cooper and Mack Hollins on the receiving corps.

We're going to take a look at the Bills' 2024 season and the rest of their offseason moves before getting into their track record in NFL futures over the last five years. After that, you can find the odds available at top sportsbooks for their 2025 win total along with Super Bowl and playoff odds as well as key player props to know. Finally, we'll take a look at the pros and cons of betting the Bills in 2025 and give out our best bets.